Review Article Research Articles

Hypertension and left ventricular hypertrophy.

In the initial stage, left ventricular hypertrophy (LVH) is adaptive, but in time, it transforms to maladaptive LVH which is specific for the development of various phenotypes that cause heart failure, initially with preserved, but later with reduced left ventricular ejection fraction. Pathophysiological mechanisms, which are characteristic for remodeling procedure, are numerous and extremely complex, and should be subjected to further research with the aim of making a comprehensive overview of hypertensive heart disease (HHD) and discovering new options for preventing and treating HHD. The contemporary methods, such as cardiac magnetic resonance (CMR) and computed tomography (CT) provide very accurate morphological and functional information on HHD. The objective of this review article is to summarize the available scientific information in terms of prevalence, pathophysiology, diagnostics, prevention, contemporary therapeutic options, as well as to present potential therapeutic solutions based on the research of pathological mechanisms which are at the core of HHD.

Role of cognitive and emotional empathy in the development of social cognition among adolescents

Empathy and social cognition among adolescents have been mainly studied in recent years. There are several reasons that adolescence and social cognition are being studied. Adolescents find themselves fully facing the external world and equipped with social cognitive skills, including emotional and cognitive empathy, along with the theory of mind acquired at home or school. Now, they must interact with others with diverse views, thoughts, and emotions from society. One of the fundamental components of social cognition among adolescents is described as empathy. Archival techniques are used in this review paper. This paper explores the connection between empathy and social cognition in adolescent development and how emotional and cognitive empathy influence social cognitive skills. It also investigates the changes in brain regions to social cognition and empathy among adolescents. Identifying this relationship reveals that emotional and cognitive empathy are both indispensable in the construct of social cognition during the adolescence period. The findings of the study point to the need for assessing the different components of empathy in psychopathological conditions among adolescents, which is marked by difficulties in emotional identification and expression. Developing a typical training program that improves social cognitive skills may help adolescents track their behavior in every aspect.

A small review on recent advances in transdermal drug delivery system

Transdermal drug delivery devices (TDDS), often known as "patches," are dosage forms designed to transfer a therapeutically effective amount of medicine over a patient's skin. Transdermal distribution establishes one of the most important channels for a revolutionary medication delivery method. Transdermal drug delivery has various advantages over traditional delivery methods, such as oral and injection; however, its efficacy is restricted. Transdermal administration traditionally entails pushing a patch containing a medicinal substance onto the skin, which is both convenient and painless, as well as therapeutic first-pass metabolism. It can deliver medications through the skin portal to systemic circulation at a predefined rate while maintaining therapeutically efficacious concentrations for an extended period of time. Around 74% of medications are taken orally, and one has been discovered to be less effective than expected.In this present review article, it covers a brief outline of various recent approaches in their development for transdermal patches.

Material Engineering Strategies for Efficient Hydrogen Evolution Reaction Catalysts.

Water electrolysis, a key enabler of hydrogen energy production, presents significant potential as a strategy for achieving net-zero emissions. However, the widespread deployment of water electrolysis is currently limited by the high-cost and scarce noble metal electrocatalysts in hydrogen evolution reaction (HER). Given this challenge, design and synthesis of cost-effective and high-performance alternative catalysts have become a research focus, which necessitates insightful understandings of HER fundamentals and material engineering strategies. Distinct from typical reviews that concentrate only on the summary of recent catalyst materials, this review article shifts focus to material engineering strategies for developing efficient HER catalysts. In-depth analysis of key material design approaches for HER catalysts, such as doping, vacancy defect creation, phase engineering, and metal-support engineering, are illustrated along with typical research cases. A special emphasis is placed on designing noble metal-free catalysts with a brief discussion on recent advancements in electrocatalytic water-splitting technology. The article also delves into important descriptors, reliable evaluation parameters and characterization techniques, aiming to link the fundamental mechanisms of HER with its catalytic performance. In conclusion, it explores future trends in HER catalysts by integrating theoretical, experimental and industrial perspectives, while acknowledging the challenges that remain.

Advancements in machine learning for predicting phases in high-entropy alloys: a comprehensive review

High entropy alloys (HEAs) are distinguished by their enhanced physicochemical properties, attributed to the formation of various phases such as solid solution (SS), intermetallic (IM), or a combination (SS + IM). These phases contribute distinctively to the microstructure of the alloys. A critical aspect of alloy design revolves around accurately predicting these phases, which has led to the integration of sophisticated data vetting methods and Machine Learning (ML) algorithms in recent research. This review paper aims to provide a comprehensive analysis of the advancements in phase prediction accuracy within HEAs, an essential component in the development of these alloys. HEAs are known for their intricate compositions, offering a wide spectrum of material properties, making them particularly relevant for applications aimed at future sustainability. Phase engineering in HEAs unlocks the potential for creating materials tailored to eco-friendly technologies and energy-efficient solutions. The challenge in predicting phase selection in HEAs is accentuated by the limited data available on these complex materials. This review delves into how advanced data vetting techniques and ML algorithms are being employed to overcome these challenges, thus contributing significantly to sustainable material design. The paper examines various algorithms used in HEA phase prediction, including KNN (K-Nearest Neighbors), SVM (Support Vector Machines), ANN (Artificial Neural Networks), GNB (Gaussian Naive Bayes), and RF (Random Forest). It discusses the testing accuracy of these algorithms in classifying HEA phases, revealing variations in their effectiveness. The review highlights the superior accuracy of ANNs, followed closely by KNN and SVM, while noting the comparatively lower accuracy of GNB. This comprehensive review synthesizes current research efforts in utilizing computational methods to design HEAs, underlining their broader implications in expediting the discovery and development of diverse metal alloys. These efforts are pivotal in meeting the evolving demands of modern engineering applications, thereby contributing to the advancement of materials science.

Client satisfaction with abortion care service and its associated factors among women in Ethiopia: a systematic review and meta-analysis

BackgroundThe client’s satisfaction after abortion care is the key to sustaining abortion care and increasing the health status of those who had complications from abortion. Nevertheless, research conducted in Ethiopia stated that the major problem is the need for post-abortion care for females. One of the ways to improve the qualities involved in post abortion care and decrease the mortality and morbidity rates caused by unsafe abortion is by ensuring client satisfaction with abortion care. Strategy making and policy formulation based on systematic review take on the highest priority in developing countries. However, although some independent studies had been carried out in Ethiopia, their findings might not have been representative and conclusive. The main purpose of this systematic review and meta-analysis article is to establish the proportion of abortion clients who are satisfied with their abortion care and the factors that contribute to such satisfaction among clients in Ethiopia.Methods and materialsOnly published articles were considered in this review. The main databases included Medline/Pubmed, Web of Science, Embase, Cinael, Med Nar, Google Scholar, Scopus, the Ethiopian University Repository Online, and the Cochrane Library. The review includes cross-sectional studies that meet the requirements and were written in English. A random effects model was used to calculate the pooled prevalence of client satisfaction with abortion care. The study heterogeneity was tested using Cochrane Q-Static and I2. Publication bias was checked using the Eggers test and funnel plot. PRISMA was used to select and direct the selection of articles for this review. Statistical analyses were conducted using STATA version 14.ResultA review of ten studies comprised 2740 women. In summary, the pooled prevalence of client’s satisfaction with abortion care in Ethiopia was 56.13% [95% CI (42.35; 69.91), I2 = 99.1%, p < 0.001]. In terms of subgroup analysis, Gambella had the highest prevalence of client satisfaction with abortion care at 87.40% [95% CI: 82.38 and 91.82]. However, Amhara had the lowest: 25.00% [95% CI: 21.59, 28.41]. The review also found that client satisfaction with abortion care had a statistical correlation with the type of procedure [OR: 0.25, CI [0.07, 0.42], I2: 76.9%, p-value: 0.041] and the participant’s education level [OR: 0.29, CI [0.09, 0.48], I2: 80.4%, p-value: 0.006].ConclusionThis review found that 56% of Ethiopian women were satisfied with their abortion care. Since this requires a boost to the quality of abortion care in the health facility, understanding women’s expectations and perceptions, training of health care providers, and strict monitoring of the quality of abortion care services by stakeholders like the Ethiopian government, non-governmental organizations, and high-level management of the health facility would help to improve the level of women’s satisfaction with abortion care. Those factors, namely, the type of method to use for the patient and women’s educational level, should be changed through improving awareness among the patients about what procedure to conduct and the health education provided to women about abortion care.

Applications of multi-parameter sensing in pharmaceutical, agriculture and mineral industries using THz spectroscopy and Low-Wavenumber Raman spectroscopy

Multi-parameter sensing using non-destructive optical spectroscopic techniques, specifically Terahertz spectroscopy and low-wavenumber Raman spectroscopy (also known as THz-Raman spectroscopy), has significantly reshaped the landscape of analytical methodologies in various industries. This comprehensive review article elucidates the transformative impact of these advanced spectroscopic methods within the fields of pharmaceutical, agriculture, and mineral industry. As technology continues to evolve, the ability to concurrently analyse multiple parameters at the molecular level has become a cornerstone for precision and efficiency in these critical sectors. In the pharmaceutical industry, THz spectroscopy has emerged as a key tool in ensuring the quality and stability of drug formulations, while low-wavenumber Raman spectroscopy complements by offering insights into chemical structure as well as composition. The agricultural sector benefits from the capabilities of these spectroscopic techniques in optimizing crop management, soil analysis, and resource utilization. Simultaneously, the mineral industry leverages THz and low-wavenumber Raman spectroscopy for accurate mineral identification, aiding in exploration, extraction, and processing. Through this review, we aim to provide a nuanced understanding of how multi-parameter sensing through THz and low-wavenumber Raman spectroscopy is driving innovation, enhancing quality control, and fostering sustainable practices across diverse industrial landscapes.

[Mini Review Article] Practicality of Piezo Surgery in Periodontics

[Mini Review Article] Practicality of Piezo Surgery in Periodontics

Oral health and multimorbidity: Is diet the chicken or the egg?

Oral health is a critical component of overall health and well-being, not just the absence of disease. The objective of this review paper is to describe relationships among diet, nutrition, oral, and systemic diseases that contribute to multi-morbidity. Diet and nutrient-related risk factors for oral diseases include high intakes of free sugars, low intakes of fruits and vegetables, and nutrient poor diets which are similar to diet and nutrient-related risk factors for systemic diseases. Oral diseases are chronic diseases. Once the disease process is initiated, it persists throughout the lifespan. Pain and tissue loss from oral disease leads to oral dysfunction which contributes to impaired biting, chewing, oral motility, and swallowing. Oral dysfunction makes it difficult to eat nutrient dense whole grains, fruits, and vegetables associated with a healthy diet. Early childhood caries (ECC) associated with frequent intake of free sugars is one of the first manifestations of oral disease. The presence of ECC is our 'canary in the coal mine' for diet-related chronic diseases. The dietary sugars causing ECC are not complementary to an Eatwell Guide compliant diet, but rather consistent with a diet high in energy dense, nutrient poor foods - typically ultra-processed in nature. This diet generally deteriorates throughout childhood, adolescence, and adulthood increasing the risk of diet-related chronic diseases. Recognition of ECC is an opportunity to intervene and disrupt the pathway to multi-morbidities. Disruption of this pathway will reduce risk of multi-morbidities and enable individuals to fully engage in society throughout the lifespan.

Far-right parties and the politics of education in Europe

ABSTRACT Formal education shapes the distribution of opportunities and cultural profile of European societies. Political parties, in turn, play a key role in shaping formal education. Focusing largely on the traditional contenders for government in Europe, research on the politics of education shows that parties prioritise redistributive issues and politicise them in line with their electorates’ material interests. It remains unclear to what extent these findings apply to a more recent, but highly successful party family: the far right. This review article and introduction to a special issue integrates existing scholarship from education and political science with findings from six new case studies from across Europe. It argues that far-right parties in Eastern and Western Europe frame education primarily as a means of disseminating (conservative and nativist) culture and values, rather than as a means of redistributing opportunities. In revaluing the cultural dimension of education for far-right partisan politics, the article and the special issue therefore not only provide insight into the educational strategies of an increasingly powerful actor in European politics, but also shed light on the mechanisms and determinants underlying the partisan dynamics that will contribute to shaping the future of European education and societies more generally.

Hepatotoxicity of Antibiotics and Antifungals and Their Safe Use in Hepatic Impairment.

Idiosyncratic drug-induced liver injury (DILI) is a rare and unpredictable form of hepatotoxicity. While its clinical course is usually benign, cases leading to liver transplantation or death can occur. Based on modern prospective registries, antimicrobials including antibiotics and antifungals are frequently implicated as common causes. Amoxicillin-clavulanate ranks as the most common cause for DILI in the Western World. Although the absolute risk of hepatotoxicity of these agents is low, as their usage is quite high, it is not uncommon for practitioners to encounter liver injury following the initiation of antibiotic or antifungal therapy. In this review article, mechanisms of hepatoxicity are presented. The adverse hepatic effects of well-established antibiotic and antifungal agents are described, including their frequency, severity, and pattern of injury and their HLA risks. We also review the drug labeling and prescription guidance from regulatory bodies, with a focus on individuals with hepatic impairment.

Clinical Presentation and Risk Stratification of Pulmonary Embolism

AbstractPulmonary embolism (PE) presents with a spectrum of symptoms, ranging from asymptomatic cases to life-threatening events. Common symptoms include sudden dyspnea, chest pain, limb swelling, syncope, and hemoptysis. Clinical presentation varies based on thrombus burden, demographics, and time to presentation. Diagnostic evaluation involves assessing symptoms, physical examination findings, and utilizing laboratory tests, including D-dimer. Risk stratification using tools like Wells score, Pulmonary Embolism Severity Index, and Hestia criteria aids in determining the severity of PE. PE is categorized based on hemodynamic status, temporal patterns, and anatomic locations of emboli to guide in making treatment decisions. Risk stratification plays a crucial role in directing management strategies, with elderly and comorbid individuals at higher risk. Early identification and appropriate risk stratification are essential for effective management of PE. As we delve into this review article, we aim to enhance the knowledge base surrounding PE, contributing to improved patient outcomes through informed decision-making in clinical practice.

Anaemia in Diabetes Mellitus

Anaemia in Diabetes Mellitus should be addressed properly. Because, anaemia in this immunocompromised state may deteriorate the physical status of this group of patients. Multiple factors have been found to be associated with anemia in Diabetes mellitus. This review article contains basic and updated concepts as well as recent studies regarding anaemia with diabetes mellitus. Bangladesh J Medicine 2024; 35: 118-121

The Protective Effects of Taurine, a Non-essential Amino Acid, Against Metals Toxicities: A Review Article.

Taurine is a non-proteinogenic amino acid derived from cysteine. It is involved in several phenomena such as the regulation of growth and differentiation, osmoregulation, neurohormonal modulation, and lipid metabolism. Taurine is important because of its high levels in several tissues such as the central nervous system (CNS), heart, skeletal muscles, retinal membranes, and platelets. In this report, we present the functional properties of taurine indicating that it has potential effects on various metal toxicities. Therefore, a comprehensive literature review was performed using the Scopus, PubMed, and Web of Science databases. According to the search keywords, 61 articles were included in the study. The results indicate that taurine protects tissues against metal toxicity through enhancement of enzymatic and non-enzymatic antioxidant capacity, modulation of oxidative stress, anti-inflammatory and anti-apoptotic effects, involvement in different molecular pathways, and interference with the activity of various enzymes. Taken together, taurine is a natural supplement that presents antitoxic effects against many types of compounds, especially metals, suggesting public consumption of this amino acid as a prophylactic agent against the incidence of metal toxicity.

Current status and future challenges of digital twins for structural health monitoring in civil infrastructures

Abstract Structural Health Monitoring (SHM) ensures the reliability, effectiveness, and performance of buildings and other structures. The introduction of digital twin technology in the last several decades has changed the field of SHM, allowing for real-time monitoring, analysis, and prediction of structural behavior. This research looks in depth at the usage of digital twins in the structural health monitoring of civil infrastructure developments. It analyzes the main features, benefits, challenges, and recent advancements in this rapidly increasing area. The review also discusses case studies and practical applications of digital twins for tracking and managing the health of civil infrastructures, providing insights into their potential for improving structural performance, lowering maintenance costs, and increasing the resilience of our built environment. This review paper provides a comprehensive overview of the usage of digital twins in critical infrastructure project structural health monitoring. It's an excellent tool for academics, scientists, and practitioners interested in utilizing digital twin technologies to improve our built environment's safety, performance, and resilience. This study aims to promote more significant research and innovation in developing and deploying digital twins for structural health monitoring by stressing the benefits, limits, and current advances in this field.&amp;#xD;

Research Progress on Taxus Extraction and Formulation Preparation Technologies

Taxus, as a globally prevalent evergreen tree, contains a wealth of bioactive components that play a crucial role in the pharmaceutical field. Taxus extracts, defined as a collection of one or more bioactive compounds extracted from the genus Taxus spp., have become a significant focus of modern cancer treatment research. This review article aims to delve into the scientific background of Taxus extracts and their considerable value in pharmaceutical research. It meticulously sifts through and compares various advanced extraction techniques such as supercritical extraction, ultrasound extraction, microwave-assisted extraction, solid-phase extraction, high-pressure pulsed electric field extraction, and enzymatic extraction, assessing each technology’s advantages and limitations across dimensions such as extraction efficiency, extraction purity, economic cost, operational time, and environmental impact, with comprehensive analysis results presented in table form. In the area of drug formulation design, this paper systematically discusses the development strategies for solid, liquid, and semi-solid dosage forms based on the unique physicochemical properties of Taxus extracts, their intended medical uses, and specific release characteristics, delving deeply into the selection of excipients and the critical technical issues in the drug preparation process. Moreover, the article looks forward to the potential directions of Taxus extracts in future research and medical applications, emphasizing the urgency and importance of continuously optimizing extraction methods and formulation design to enhance treatment efficacy, reduce production costs, and decrease environmental burdens. It provides a comprehensive set of preparation techniques and formulation optimization schemes for researchers in cancer treatment and other medical fields, promoting the application and development of Taxus extracts in pharmaceutical sciences.

The importance of sustainable practices and whole foods in Brazilian schools

This review article analyzes the importance of sustainable practices and whole foods in Brazilian schools. The qualitative data was collected from articles corresponding to the years 2018 to 2022, through access to: SCIELO, CAPES journal portal and the BDTD (Brazilian Digital Library of Theses and Dissertations) under the criteria: national and complete publications, and with the themes: (i) integral use of food; (ii) existence of the practice and incidences in the consumption of food in its entirety; (iii) investigation of the importance of sustainability and its implication today. Of the 23 articles, 14 were selected, with consultations on laws for discussion and analysis. The aim is to highlight the provocation and promotion of healthy food consumption. School communities provide food as one of the premises for forming healthy eating habits. Therefore, the SDGs: 2, 4 and 12 - zero hunger and sustainable agriculture, quality education and responsible consumption and production - are correlated with situations in which school meals reflect on food waste.

Perioperative Management of Traditional and Direct Oral Anticoagulants in Hip Fracture Patients

Hip fractures are an increasingly common injury in the senior population and almost always require surgical fixation or prosthetic replacement. These surgeries, according to the American Academy of Orthopaedic Surgeons, are considered high-risk for bleeding, especially in a population fraught with comorbidities and often presenting on anticoagulation medications. Direct oral anticoagulants represent a class of drugs that have been becoming more popular in use in this population, with many benefits over the historically used Warfarin. There are recommendations for preoperative discontinuation and postoperative resumption of these medications, which can be more readily managed for elective surgeries. However, there is a paucity of literature detailing best practice guidelines for the perioperative management of direct oral anticoagulants when a patient presents with a hip fracture. This review article summary of the periprocedural management of DOACs for hip surgery was developed by examining the American College of Chest Physicians evidence-based clinical practice guidelines, Perioperative Guidelines on Antiplatelet and Anticoagulant Agents written by anesthesiologists, various retrospective studies, and drug labels for pharmacokinetic data. These recommendations should be used as a guideline, along with the collaboration of multidisciplinary hospital teams during inpatient admission, to manage these complex patients.

Enhancing integrated resource management through remote sensing and GIS

Integrated Resource Management plays a crucial role in sustainable development by ensuring efficient allocation and utilization of natural resources. Remote Sensing (RS) and Geographic Information System (GIS) have emerged as powerful tools for collecting, analyzing, and managing spatial data, enabling comprehensive and integrated decision-making processes. This review article uniquely focuses on Integrated Resource Management (IRM) and its role in sustainable development. It specifically examines the application of RS and GIS in IRM across various resource management domains. The article stands out for its comprehensive coverage of the benefits, challenges, and future directions of this integrated approach.

Targeting KRAS Oncogene for Patients With Colorectal Cancer: A New Step Toward Precision Medicine.

KRAS mutations are common driver oncogenes associated with the development of several solid tumors. KRAS oncogene has been considered a highly challenging target for drug development because of structural features, including the lack of deep groove on its catalytic unit. However, by leveraging cysteine residues, covalent KRAS inhibitors irreversibly trap KRAS G12C mutants in their inactive GDP-bound state. These agents have resulted in significant clinical responses among patients with KRAS G12C-mutant solid tumors, including patients with colorectal cancer (CRC). Other allele-specific inhibitors of KRAS oncogene and panKRAS and panRAS inhibitors are also currently being investigated in clinical trials. This review article overviews recent clinical progress on KRAS G12C targeting for the management of patients with KRAS G12C-mutant CRC and provides an update on other RAS targeting approaches. We also discuss the unique biological features of RAS-mutant CRC, which require the combination of KRAS inhibitors and anti-epidermal growth factor receptor therapy, and elaborate on resistance mechanisms and novel therapeutic avenues that may define future treatment paradigms of patients with RAS-mutant CRC.